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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERN1
All Species:
32.42
Human Site:
S681
Identified Species:
54.87
UniProt:
O75460
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75460
NP_001424.3
977
109735
S681
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
Chimpanzee
Pan troglodytes
XP_511585
968
108684
S666
K
L
A
V
G
R
H
S
F
S
R
R
S
G
V
Rhesus Macaque
Macaca mulatta
XP_001109583
1070
119711
S774
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
Dog
Lupus familis
XP_853409
975
109686
S679
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQY0
977
110166
S681
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
Rat
Rattus norvegicus
XP_573211
965
109012
S669
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510886
942
106736
S642
S
G
L
A
Y
L
H
S
L
S
I
V
H
R
D
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001085649
958
108223
S672
S
G
L
A
H
L
H
S
L
N
I
V
H
R
D
Zebra Danio
Brachydanio rerio
XP_001919350
921
102695
S639
C
G
L
S
H
L
H
S
L
N
I
V
H
R
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097839
1074
120152
L658
A
A
S
G
L
S
H
L
H
S
L
D
I
V
H
Honey Bee
Apis mellifera
XP_392044
968
110555
R648
P
G
P
R
G
E
V
R
A
M
I
S
D
F
G
Nematode Worm
Caenorhab. elegans
Q09499
967
109804
E652
T
M
A
S
Q
R
G
E
M
R
A
V
I
S
D
Sea Urchin
Strong. purpuratus
XP_786178
1112
123199
L700
G
L
A
H
L
H
S
L
N
I
V
H
R
D
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32361
1115
126957
G784
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.7
90.3
95.5
N.A.
93.1
92.1
N.A.
83
N.A.
56
57
N.A.
37.7
43
41.3
41.4
Protein Similarity:
100
84.8
91
97.3
N.A.
96.3
94.8
N.A.
89.3
N.A.
71.4
69.8
N.A.
52.9
58.6
59.3
54.4
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
86.6
N.A.
100
86.6
N.A.
6.6
13.3
13.3
0
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
100
N.A.
100
93.3
N.A.
26.6
13.3
33.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
25.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
22
50
0
8
0
0
8
8
8
0
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
8
8
8
65
% D
% Glu:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% F
% Gly:
8
65
0
8
15
0
8
8
0
0
0
0
0
8
8
% G
% His:
0
0
0
8
50
8
72
0
8
0
8
8
65
0
8
% H
% Ile:
0
0
0
0
8
0
0
0
0
8
65
0
15
0
8
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
8
22
58
0
15
58
0
15
58
0
8
8
0
0
8
% L
% Met:
0
8
0
0
0
0
0
0
8
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
50
0
0
0
0
0
% N
% Pro:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
8
8
0
15
0
8
0
8
8
8
8
58
0
% R
% Ser:
50
0
8
15
0
8
15
65
0
22
0
8
8
15
0
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
8
0
0
8
0
8
0
8
65
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _